Endocrine Abstracts

Introduction: Primary adrenal insufficiency or Addison disease (AD) is a potentially fatal condition if not diagnosed in time. Rarely, it can arise as a manifestation of antiphospholipid syndrome (APS), caused by adrenal venous thrombosis and consequent hemorrhagic infarction.Case report: We present the case of a 36-year-old caucasian woman with APS diagnosis since she was 24, with history of arterial hypertension and multiple thrombotic events (deep vei...

Introduction: In addition to the medication prescribed by their doctors, patients may recourse to natural medicine and take herbal medications without thinking about their potential side effects and interactions with other drugs.Case Report: A 39-year-old female, with personal history of iron deficiency anemia, regular menses but long-standing dysmenorrhea and polymenorrhea and reactive anxiety-depressive disorder, complained of frequent intermenstrual s...

Gestational diabetes mellitus (GDM) is associated with an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to screen for PIH and preeclampsia in normotensive type 1 diabetic women. To date, there are no data regarding ABPM in women with GDM. The aim of the study was to establish blood pressure (BP) profiles for pregnant with GDM, using ABPM and determine whether a BP pattern can define a population at risk for de...

Introduction: Hyperglycemia (irrespective of the presence of diabetes) has been associated with worse outcomes in hospitalized patients with a variety of diseases, namely critical illness. It is been recently proposed that a relative hyperglycemia – Stress Hyperglycemia Ratio (SHR) – might be even better associated with disease outcomes. We studied how SHR correlated with various morbidity parameters in hospitalized patients due to acute pyelonephritis.<p class="...

Background: Insulin-related peptides are found in Cnidaria (the most ancient animals with differentiated tissues including a nervous system, dating from 600 million years ago) and their nucleotide sequence has been highly preserved ever since. In mammals the binding of insulin to its receptor causes a cascade of actions, the main one being translocation of GLUT4 glucose transporters to the plasma membrane allowing influx of glucose into the adipose and striated muscle cells. B...

Introduction: Spontaneous fertility in Turner syndrome (TS) is rare, due to low or absent ovarian reserve. A greater number of ovarian follicules is present in the cases of gonadal mosaicism, although the accelerated pace of apoptosis remains. Thus, the early referral to reproductive counseling is advisable, ideally soon after diagnosis. The criopreservation of oocytes is one of the options for fertility preservation. The authors present a series of 7 patients with TS admitted...

Introduction: Neuroglucopenic hypoglycaemia might be an underestimated threat of bariatric surgery, as Roux-en-Y gastric bypass (RYBG) or gastric sleeve. We aimed to evaluate glucose variability after bariatric surgery by continuous glucose monitoring (CGM) in a real-life setting.Methods: CGM was used in twelve patients with clinical suspicion of hypoglycaemia after undergoing bariatric surgery (RYBG or sleeve), during seven days. CGM was through using i...

Introduction: The prevalence of obesity has increased, reaching epidemic proportions. Framingham and REGICOR scales predict the likelihood of developing a coronary event in the next 10 years. The aim of this study was to assess the concordance of these scales in the stratification of cardiovascular risk (CVR) in a cohort of patients with morbid obesity.Methods: We designed a cross-sectional study in a sample of patients with morbid obesity evaluated from...

Introduction: Craniopharyngiomas are rare epithelial tumors of the sellar and parasellar region, with high survival rates but with frequent tumor recurrence or persistence.Methods: Information collection from clinical records and review of the epidemiology, diagnosis, treatment and follow-up of patients with diagnosis of craniopharyngioma followed in an Endocrinology Department between 1980 and 2015. Statistical analysis using SPSS v. 22.0.<p class="...

Introduction and objectives: Testosterone therapy (TT) in female-to-male transsexuals (FMT) usually causes cessation of menses within the first few months. However the changes in the hormonal profile are not well known. We set out to analyze the hormonal changes and menstrual evolution in a cohort of FMT who began TT.Methodology: Retrospective observational study with no control group in a cohort of 34 FMT patients who started TT following a standard pro...